Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5545429 | 0.84 | GSK3B (0.46) | MAPTGSK3AGSK3B | |
| SCHEMBL5550039 | 0.83 | GSK3A (0.46) | MAPTMEN1POLBKMT2AGSK3A | |
| SCHEMBL3522851 | 0.78 | CXCR2 (0.35) | — | |
| SCHEMBL5548540 | 0.77 | PDE5A (0.32) | L3MBTL1MAPTKDM4EGSK3AGSK3B | |
| SCHEMBL3529920 | 0.77 | GSK3A (0.61) | L3MBTL1MEN1KMT2AKDM4EGSK3A | |
| SCHEMBL5549261 | 0.73 | KMT2A (0.48) | MAPK1MAPTMEN1POLBKMT2A | |
| SCHEMBL5543524 | 0.72 | ADORA1 (0.43) | GSK3AGSK3B | |
| SCHEMBL5543493 | 0.72 | GSK3B (0.50) | MAPTGSK3AGSK3BSMN1; SMN2 | |
| SCHEMBL5549402 | 0.72 | ADORA1 (0.43) | MAPTMEN1KMT2AGSK3AGSK3B | |
| SCHEMBL5548609 | 0.72 | MAPK1 (0.37) | MAPK1MEN1KMT2AGSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |