Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547096 | 0.78 | KDM4E (0.48) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL8596016 | 0.75 | MAPT (0.48) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL25846851 | 0.75 | LOXL2 (0.52) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL30002633 | 0.75 | MAPT (0.48) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL7119359 | 0.75 | ALDH1A1 (0.48) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL2340487 | 0.75 | MAPT (0.48) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3820241 | 0.75 | MAPT (0.48) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL18617684 | 0.75 | MAPT (0.48) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL24522644 | 0.74 | HDAC6 (0.71) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL5550516 | 0.73 | KDM4E (0.34) | MAPTKDM4EHDAC6THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101107000-A | 3,6-bicyclolides | ENANTA PHARM INC (US) | 2008-01-16 | — | — | CN | disclosed |
| EP-1830858-A2 | 3, 6-BICYCLOLIDES | Enanta Pharmaceuticals, Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006063039-A2 | 3, 6-BICYCLOLIDES | ENANTA PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |