Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DEGS1 | O15121 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5550017 | 0.75 | PIK3C3 (0.45) | — | |
| SCHEMBL26653746 | 0.73 | HSD17B10 (0.54) | NPSR1RAB9ASMN1; SMN2NPC1TDP1 | |
| SCHEMBL5549486 | 0.73 | CDK8 (0.42) | MEN1KMT2A | |
| SCHEMBL4160236 | 0.73 | RAB9A (0.48) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL3408832 | 0.71 | TSHR (0.68) | RAB9ASMN1; SMN2NPC1TSHRDEGS1 | |
| SCHEMBL4164891 | 0.70 | RAB9A (0.50) | RAB9ASMN1; SMN2NPC1KMT2ATSHR | |
| SCHEMBL1989892 | 0.70 | KDR (0.47) | RAB9ASMN1; SMN2NPC1MAPTDEGS1 | |
| SCHEMBL16230884 | 0.70 | TSHR (0.46) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL4166156 | 0.70 | RAB9A (0.43) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL6363003 | 0.69 | L3MBTL1 (0.38) | HTTNPSR1RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828180-A1 | 1H-PYRROLO[2,3-BETA]PYRIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006063167-A1 | 1H-PYRROLO[2,3-B]PYRIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-15 | — | — | WO | disclosed |