Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5545360 | 0.84 | POLB (0.40) | POLBTP53KMT2AMAPTMAPK1 | |
| SCHEMBL5538554 | 0.76 | PTGS2 (0.39) | KMT2AMAPTMEN1 | |
| SCHEMBL5540825 | 0.74 | LMNA (0.46) | KMT2AMAPTMAPK1SMN1; SMN2MEN1 | |
| SCHEMBL5540834 | 0.69 | ALDH1A1 (0.46) | TP53KMT2AMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL14065327 | 0.69 | KDM4E (0.47) | TP53KMT2AMAPTMAPK1SMN1; SMN2 | |
| SCHEMBL9515069 | 0.68 | KDM4E (0.49) | POLBTP53KMT2AMAPTMAPK1 | |
| SCHEMBL13851063 | 0.67 | KDM4E (0.46) | KMT2ASMN1; SMN2LTA4HMEN1 | |
| SCHEMBL15163611 | 0.67 | PTGS2 (0.38) | KMT2AMAPTMEN1 | |
| SCHEMBL5540917 | 0.66 | LMNA (0.46) | POLBTP53MAPK1 | |
| SCHEMBL13851059 | 0.65 | BRD4 (0.52) | KMT2AMAPK1SMN1; SMN2LTA4HMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070124152-A1 | Hiv Integrase Inhibitors | GLAXOSMITHKLINE LLC | 2007-05-31 | — | — | US | disclosed |