Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.44 |
| ▸ | LTA4H | P09960 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.44 |
| ▸ | GABRP | O00591 | 2/20 | 0.44 |
| ▸ | GABRD | O14764 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9515069 | 0.88 | KDM4E (0.49) | KDM4EKMT2AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL5540834 | 0.86 | ALDH1A1 (0.46) | KDM4EKMT2AMAPK1SMN1; SMN2GABRA1 | |
| SCHEMBL13851063 | 0.86 | KDM4E (0.46) | KDM4EKMT2ASMN1; SMN2GABRA1GABRA3 | |
| SCHEMBL11630841 | 0.84 | RNASEH1 (0.42) | ALDH1A1HPGDLMNA | |
| SCHEMBL13851064 | 0.84 | KDM4E (0.48) | KDM4EKMT2AMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL5545422 | 0.81 | LTA4H (0.44) | KDM4EKMT2AL3MBTL1SMN1; SMN2GABRA1 | |
| SCHEMBL14065332 | 0.80 | BRD4 (0.42) | KDM4EKMT2ASMN1; SMN2GABRA1GABRA3 | |
| SCHEMBL13851059 | 0.80 | BRD4 (0.52) | KMT2AMAPK1SMN1; SMN2LTA4HRAB9A | |
| SCHEMBL16999960 | 0.79 | RAB9A (0.42) | KDM4EKMT2AL3MBTL1SMN1; SMN2GABRA1 | |
| SCHEMBL13851060 | 0.78 | RAB9A (0.54) | KDM4EKMT2ASMN1; SMN2GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8691991-B2 | 2-oxonaphthyridine-3-carboxamides HIV integrase inhibitors | SHIONOGI & CO., LTD. (JP) | 2014-04-08 | — | — | US | disclosed |
| US-20080234231-A1 | Hiv Integrase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-09-25 | — | — | US | disclosed |
| US-20080214527-A1 | Hiv Integrase Inhibitors | SHIONOGI & CO. LTD (JP) | 2008-09-04 | — | — | US | disclosed |
| US-20080214503-A1 | Hiv Integrase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-09-04 | — | — | US | disclosed |
| US-20080194523-A1 | Hiv Integrase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2008-08-14 | — | — | US | disclosed |
| US-20070124152-A1 | Hiv Integrase Inhibitors | GLAXOSMITHKLINE LLC | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214527-A1 | Hiv Integrase Inhibitors | API5, ING2, SAMHD1 | KDM4E 1139/4885KMT2A 682/4885MAPK1 2495/4885 |
| US-20080214503-A1 | Hiv Integrase Inhibitors | SAMHD1, ACIN1, API5 | KDM4E 2653/4885KMT2A 1762/4885MAPK1 2563/4885 |
| US-20080194523-A1 | Hiv Integrase Inhibitors | ING2, API5, SAMHD1 | KDM4E 1183/4885KMT2A 816/4885MAPK1 2268/4885 |
| US-20080234231-A1 | Hiv Integrase Inhibitors | ING2, API5, SAMHD1 | KDM4E 1183/4885KMT2A 816/4885MAPK1 2268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.