Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL810754 | 0.71 | KDM4E (0.37) | HSD17B10KDM4EALDH1A1GAAMAPT | |
| SCHEMBL2706154 | 0.70 | LMNA (0.47) | HSD17B10KDM4EALDH1A1GAAMAPT | |
| SCHEMBL6471018 | 0.70 | CYP2A6 (0.37) | — | |
| SCHEMBL4888542 | 0.69 | CYP17A1 (0.50) | HSD17B10KDM4EALDH1A1GAAMAPT | |
| SCHEMBL5759519 | 0.68 | NTRK1 (0.35) | RAB9APDE10A | |
| SCHEMBL5750912 | 0.68 | HTR2C (0.49) | KDM4EALDH1A1MAPTKMT2ANPSR1 | |
| SCHEMBL718221 | 0.67 | KDM4E (0.37) | KDM4EALDH1A1KMT2ALMNA | |
| SCHEMBL4870334 | 0.67 | KDM4E (0.49) | HSD17B10KDM4EALDH1A1GAAMAPT | |
| SCHEMBL11097221 | 0.64 | CSNK1A1 (0.61) | KDM4EALDH1A1KMT2AMEN1HPGD | |
| SCHEMBL10981062 | 0.64 | MAPK1 (0.54) | HSD17B10KDM4EALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108774248-A | Method for preparing thiazoloquinazolinone derivative | 苏州大学 | 2018-11-09 | — | — | CN | claimed |
| CN-108774248-A | Method for preparing thiazoloquinazolinone derivative | 苏州大学 | 2018-11-09 | — | — | CN | disclosed |
| CN-108774248-A | Method for preparing thiazoloquinazolinone derivative | 苏州大学 | 2018-11-09 | — | — | CN | disclosed |
| US-7235572-B2 | Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents | HOFFMAN-LA ROCHE INC. (US) | 2007-06-26 | — | — | US | disclosed |
| US-20050004187-A1 | Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. | 2005-01-06 | — | — | US | disclosed |
| US-3964894-A | 1-(FURYL OR THIAZOLYL)CARBONYL-2-METHYL-5-METHOXY-INDOL-3-YL ACETIC ACID | CHINOIN GYOGYSZER-ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1976-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004187-A1 | Thiazolyl-indole derivatives, their manufacture and use as pharmaceutical agents | PPARD, PPARA, PPARG | HSD17B10 687/4885KDM4E 1998/4885ALDH1A1 627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.