Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.48 |
| ▸ | HTR3A | P46098 | 4/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.48 |
| ▸ | HTR3B | O95264 | 3/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL894537 | 0.87 | ADRB1 (0.63) | MAOBHTR7HTR1AKDM4ETP53 | |
| SCHEMBL233425 | 0.87 | ADRB1 (0.63) | MAOBHTR7HTR1AKDM4ETP53 | |
| Hydrochloric Acid SCHEMBL714521 | 0.85 | ADRB1 (0.61) | MAOBHTR7HTR1AKDM4ETP53 | |
| Bromide SCHEMBL10674981 | 0.85 | ADRB1 (0.61) | MAOBHTR7HTR1AKDM4ETP53 | |
| Piperazine SCHEMBL7486912 | 0.85 | ADRB1 (0.61) | MAOBHTR7HTR1AKDM4ETP53 | |
| Hydrochloric Acid SCHEMBL1005870 | 0.85 | ADRB1 (0.61) | MAOBHTR7HTR1AKDM4ETP53 | |
| SCHEMBL943026 | 0.82 | HTR7 (0.70) | MAOBHTR7HTR1AKDM4ETP53 | |
| SCHEMBL5237662 | 0.80 | HTR3A (0.57) | MAOBHTR7HTR1AKDM4ETP53 | |
| Hydrochloric Acid SCHEMBL943219 | 0.80 | HTR7 (0.68) | MAOBHTR7HTR1AKDM4ETP53 | |
| SCHEMBL3781270 | 0.79 | ADRB1 (0.77) | HTR7HTR1AKDM4EADRB1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107207515-B | Pyrazine compounds for the treatment of infectious diseases | 豪夫迈·罗氏有限公司 | 2019-05-28 | — | — | CN | disclosed |
| CN-105073751-B | The substituted imidazoles new as Casein kinase 1 δ/epsilon inhibitor | 百时美施贵宝公司 | 2018-11-30 | — | — | CN | disclosed |
| CN-107207515-A | Pyrazine compounds for the treatment of infectious diseases | 豪夫迈·罗氏有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-107011343-A | Novel pyrazole derivative | 持田制药株式会社 | 2017-08-04 | — | — | CN | disclosed |
| CN-106957317-A | Novel pyrazole derivative | 持田制药株式会社 | 2017-07-18 | — | — | CN | disclosed |
| CN-105189493-B | Novel Pyrazole Derivatives | 持田制药株式会社 | 2017-04-12 | — | — | CN | disclosed |
| CN-105073751-A | Novel substituted imidazoles as casein kinase 1 [delta]/[epsilon] inhibitors | BRISTOL MYERS SQUIBB CO | 2015-11-18 | — | — | CN | disclosed |
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| CN-102471341-A | Compounds and compositions for the treatment of parasitic diseases | IRM LLC | 2012-05-23 | — | — | CN | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-05-04 | — | — | US | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |
| CN-1139589-C | Tetrahydroimidazo [2,1-a] isoquinoline derivatives | ��˹��ŵ�� | 2004-02-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | NR2C2, NR4A3, NR4A2 | MAOB 2140/4885HTR7 3656/4885HTR1A 4141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.