SCHEMBL5548831

SCHEMBL5548831

CCCCCc1ccc(C=Cc2ccc3cc4cc5ccccc5cc4cc3c2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RELA Q04206 1/20 0.50
ALDH1A1 P00352 2/20 0.46
GLA P06280 1/20 0.46
MAPT P10636 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
BCHE P06276 2/20 0.45
CYSLTR2 Q9NS75 2/20 0.43
CYSLTR1 Q9Y271 2/20 0.43
TRPA1 O75762 1/20 0.43
TRPM2 O94759 1/20 0.43
PLA2G1B P04054 1/20 0.43
TRPM8 Q7Z2W7 1/20 0.43
NQO2 P16083 2/20 0.43
CHRNB4 P30926 1/20 0.43
CHRNA3 P32297 1/20 0.43
CHRNA7 P36544 1/20 0.43
THRB P10828 1/20 0.42
SPHK2 Q9NRA0 1/20 0.42
SPHK1 Q9NYA1 1/20 0.42
PTGS1 P23219 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5551483 0.98 RELA (0.49) RELAALDH1A1GLAMAPTSMN1; SMN2
SCHEMBL15465910 0.98 RELA (0.49) RELAALDH1A1GLAMAPTSMN1; SMN2
SCHEMBL4586322 0.95 THRB (0.45) RELAALDH1A1TRPM2THRBSPHK2
SCHEMBL1594366 0.95 THRB (0.45) RELAALDH1A1TRPM2THRBSPHK2
SCHEMBL30969698 0.93 SIGMAR1 (0.45) RELAALDH1A1GLAMAPTSMN1; SMN2
SCHEMBL30969697 0.93 SIGMAR1 (0.45) RELAALDH1A1GLAMAPTSMN1; SMN2
SCHEMBL29266161 0.93 SIGMAR1 (0.45) RELAALDH1A1GLAMAPTSMN1; SMN2
SCHEMBL29266153 0.91 SIGMAR1 (0.48) RELAALDH1A1GLAMAPTSMN1; SMN2
SCHEMBL29266167 0.91 SIGMAR1 (0.48) RELAALDH1A1GLAMAPTSMN1; SMN2
SCHEMBL29266162 0.88 ESR1 (0.43) ALDH1A1THRBPTGS1ESR1ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869720-A2 ARYL-ETHYLENE SUBSTITUTED AROMATIC COMPOUNDS AND THEIR USE AS ORGANIC SEMICONDUCTORS E.I.Du pont de nemours and company (US) 2007-12-26 EP disclosed
WO-2006113205-A2 ARYL-ETHYLENE SUBSTITUTED AROMATIC COMPOUNDS AND THEIR USE AS ORGANIC SEMICONDUCTORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2006-10-26 WO disclosed