Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.33 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
| ▸ | GABRD | O14764 | 2/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.33 |
| ▸ | GABRE | P78334 | 2/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.33 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.33 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.33 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17843997 | 0.86 | KDM4E (0.45) | KDM4EPKMCLCN2ADORA2AATR | |
| SCHEMBL28357565 | 0.81 | KDM4E (0.41) | KDM4EPKMCLCN2ADORA2AGAA | |
| SCHEMBL27582958 | 0.77 | KDM4E (0.43) | KDM4EPKMADORA2AGAARAB9A | |
| SCHEMBL21092113 | 0.76 | FGFR1 (0.38) | KDM4EPKMADORA2ARAB9AATR | |
| Hydrochloric Acid SCHEMBL27583077 | 0.76 | KDM4E (0.42) | KDM4EPKMADORA2AGAARAB9A | |
| SCHEMBL27920106 | 0.72 | KDM4E (0.47) | KDM4EPKMRAB9ARORBSMN1; SMN2 | |
| SCHEMBL24508661 | 0.71 | ALDH1A2 (0.47) | KDM4EPKMADORA2AGAARAB9A | |
| SCHEMBL24509432 | 0.71 | RORB (0.46) | KDM4EPKMRAB9AMEN1KMT2A | |
| SCHEMBL1561051 | 0.70 | KDM4E (0.46) | KDM4EPKMADORA2AADORA1GAA | |
| SCHEMBL17843999 | 0.70 | ALDH1A1 (0.43) | KDM4EGABRA1GABRB2GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002000649-A9 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |