Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15677756 | 0.77 | RAB9A (0.53) | ALDH1A1KMT2AMEN1SMN1; SMN2NPSR1 | |
| SCHEMBL5547469 | 0.76 | LMNA (0.60) | ALDH1A1KMT2AMEN1MAPTHTT | |
| SCHEMBL31453688 | 0.75 | KMT2A (0.59) | ALDH1A1KMT2AMEN1TRPA1NPSR1 | |
| SCHEMBL9008342 | 0.75 | KMT2A (0.59) | ALDH1A1KMT2AMEN1TRPA1NPSR1 | |
| SCHEMBL5550812 | 0.75 | LMNA (0.62) | ALDH1A1KMT2AMEN1MAPTCYP1A2 | |
| SCHEMBL25385990 | 0.73 | PLA2G1B (0.57) | ALDH1A1KMT2AMEN1NPSR1MAPT | |
| SCHEMBL12218448 | 0.73 | MEN1 (0.86) | ALDH1A1KMT2AMEN1SMN1; SMN2HTT | |
| SCHEMBL5550113 | 0.72 | NPC1 (0.55) | ALDH1A1KMT2AMEN1TRPA1SMN1; SMN2 | |
| SCHEMBL1241022 | 0.72 | SOS1 (0.54) | ALDH1A1KMT2AMEN1TRPA1SMN1; SMN2 | |
| SCHEMBL14465084 | 0.71 | MEN1 (0.89) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002000649-A9 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2007-09-20 | — | — | WO | disclosed |
| EP-1299381-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | AstraZeneca AB (SE) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002000649-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |