SCHEMBL5555666

SCHEMBL5555666

COCOC(=O)C=CC#N

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 3/20 0.33
ATM Q13315 1/20 0.33
KEAP1 Q14145 1/20 0.32
NFE2L2 Q16236 1/20 0.32
ZDHHC20 Q5W0Z9 1/20 0.31
ZDHHC2 Q9UIJ5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8925744 0.82 HCAR2 (0.48) HCAR2ATMKEAP1NFE2L2
SCHEMBL10394952 0.82 HCAR2 (0.48) HCAR2ATMKEAP1NFE2L2
SCHEMBL487322 0.82 ATM (0.41) HCAR2ATMKEAP1NFE2L2
SCHEMBL828236 0.80 HCAR2 (0.39) HCAR2ATMZDHHC20ZDHHC2
SCHEMBL440642 0.79 ATM (0.47) HCAR2ATMZDHHC20ZDHHC2
SCHEMBL540751 0.79 ATM (0.47) HCAR2ATM
SCHEMBL29446 0.78
SCHEMBL600328 0.78
SCHEMBL442803 0.78
SCHEMBL4893048 0.77 TSHR (0.42) HCAR2ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10471174-B2 Cyanoacrylate medical adhesive and preparation method and use thereof Shen, Wei (CN) 2019-11-12 US claimed
EP-3335738-B1 NEW TYPE CYANOACRYLATE MEDICAL ADHESIVE AND PREPARATION METHOD AND USE THEREOF SHEN WEI (CN) 2019-11-06 EP claimed
US-20190175782-A1 NOVEL CYANOACRYLATE MEDICAL ADHESIVE AND PREPARATION METHOD AND USE THEREOF SHEN, WEI (CN) 2019-06-13 US claimed
EP-3335738-A1 NEW TYPE CYANOACRYLATE MEDICAL ADHESIVE AND PREPARATION METHOD AND USE THEREOF Shen, Wei (CN) 2018-06-20 EP claimed
US-10471174-B2 Cyanoacrylate medical adhesive and preparation method and use thereof Shen, Wei (CN) 2019-11-12 US disclosed
EP-3335738-B1 NEW TYPE CYANOACRYLATE MEDICAL ADHESIVE AND PREPARATION METHOD AND USE THEREOF SHEN WEI (CN) 2019-11-06 EP disclosed
US-20190175782-A1 NOVEL CYANOACRYLATE MEDICAL ADHESIVE AND PREPARATION METHOD AND USE THEREOF SHEN, WEI (CN) 2019-06-13 US disclosed
EP-3335738-A1 NEW TYPE CYANOACRYLATE MEDICAL ADHESIVE AND PREPARATION METHOD AND USE THEREOF Shen, Wei (CN) 2018-06-20 EP disclosed
EP-1360257-B1 CYANOACRYLATE COMPOSITIONS CURABLE TO FLEXIBLE POLYMERIC MATERIALS LOCTITE R & D LTD (IE) 2007-07-25 EP disclosed
US-6977278-B1 Cyanoacrylate compositions curable to flexible polymeric materials LOCTITE (R&D) LTD. (IE) 2005-12-20 US disclosed
EP-1360257-A1 CYANOACRYLATE COMPOSITIONS CURABLE TO FLEXIBLE POLYMERIC MATERIALS Loctite (R & D) Limited (IE) 2003-11-12 EP disclosed
WO-2002053666-A1 CYANOACRYLATE COMPOSITIONS CURABLE TO FLEXIBLE POLYMERIC MATERIALS LOCTITE (R & D) LIMITED (IE) 2002-07-11 WO disclosed