Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.30 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.30 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.30 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554035 | 0.98 | ABCB11 (0.33) | ABCB11PROKR1ALDH1A1LMNAHPGD | |
| SCHEMBL5558835 | 0.85 | ABCB11 (0.38) | ABCB11ALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL5558610 | 0.83 | PTGS2 (0.43) | ABCB11LMNAKMT2AMAPT | |
| SCHEMBL5554313 | 0.80 | ABCB11 (0.38) | ABCB11MAPT | |
| SCHEMBL5560622 | 0.78 | ABCB11 (0.33) | ABCB11MAPTTAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5553945 | 0.75 | PTGS2 (0.40) | ABCB11LMNAKMT2AMAPT | |
| SCHEMBL5559012 | 0.74 | — | — | |
| SCHEMBL5558830 | 0.71 | AKR1C3 (0.36) | PROKR1HPGDKMT2AMAPK7 | |
| SCHEMBL5560437 | 0.70 | PTGS2 (0.42) | ABCB11LMNAKMT2AMAPT | |
| SCHEMBL5554806 | 0.70 | CNR2 (0.36) | ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |