Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 2/20 | 0.35 |
| ▸ | PRKACG | P22612 | 2/20 | 0.35 |
| ▸ | PRKACB | P22694 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 3/20 | 0.33 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553945 | 0.90 | PTGS2 (0.40) | AKR1C3AKR1C2MEN1KMT2APTGDR2 | |
| SCHEMBL5558610 | 0.78 | PTGS2 (0.43) | AKR1C3AKR1C2MEN1KMT2APTGDR2 | |
| SCHEMBL5558391 | 0.77 | SRC (0.42) | AKR1C3AKR1C2SRCPRKACAPRKACG | |
| SCHEMBL5558909 | 0.75 | MAPK7 (0.39) | MGLLMAPK7PTGS2 | |
| SCHEMBL5559277 | 0.75 | SCN9A (0.37) | MGLLMAPK7PTGS2 | |
| SCHEMBL5553718 | 0.75 | PTGS2 (0.38) | AKR1C3AKR1C2MEN1KMT2APTGDR2 | |
| SCHEMBL5560487 | 0.74 | PDE2A (0.37) | AKR1C3AKR1C2MGLLPTGS2 | |
| SCHEMBL5559446 | 0.74 | MAPK7 (0.39) | MGLLMAPK7PTGDR2 | |
| SCHEMBL5556641 | 0.71 | ABCB11 (0.33) | MAPK7HPGDKMT2APROKR1 | |
| SCHEMBL5559111 | 0.71 | PPARG (0.40) | AKR1C3AKR1C2MEN1KMT2APTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |