Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5557342 | 0.93 | KMT2A (0.47) | HPGDALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL5552796 | 0.91 | MAPT (0.42) | MRGPRX4HPGDALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5558769 | 0.87 | MAPT (0.46) | HPGDALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL6154251 | 0.86 | NR1H4 (0.54) | MRGPRX4NR1H4MEN1NPC1POLB | |
| SCHEMBL5552375 | 0.86 | HDAC1 (0.41) | MRGPRX4NR1H4MEN1KMT2AFFAR1 | |
| SCHEMBL5552894 | 0.82 | HDAC6 (0.55) | NR1H4MEN1KMT2ANR4A2GCK | |
| SCHEMBL6162257 | 0.80 | PIK3CD (0.40) | HPGDALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL6155082 | 0.79 | PIK3CD (0.41) | HPGDALDH1A1SMN1; SMN2MEN1NPC1 | |
| SCHEMBL6682432 | 0.78 | RAB9A (0.53) | NR1H4ALDH1A1MEN1NPC1POLB | |
| SCHEMBL5558493 | 0.77 | MAPT (0.36) | MRGPRX4HPGDALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197577-A1 | Inhibitors of anthrax lethal factor | CENGENT THERAPEUTICS (US) | 2007-08-23 | — | — | US | disclosed |
| WO-2005027856-A2 | INHIBITORS OF ANTHRAX LETHAL FACTOR | CENGENT THERAPEUTICS (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197577-A1 | Inhibitors of anthrax lethal factor | APAF1, ANTXR2, LITAF | MRGPRX4 2180/4885NR1H4 3604/4885HPGD 1394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.