Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 4/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17901794 | 0.82 | SMN1; SMN2 (0.46) | HPGDALDH1A1HTTGAAMEN1 | |
| SCHEMBL23718824 | 0.82 | SMN1; SMN2 (0.46) | HPGDALDH1A1HTTGAAMEN1 | |
| SCHEMBL7304374 | 0.80 | HPGD (0.40) | HPGDALDH1A1HTTMMP1MMP2 | |
| SCHEMBL7346646 | 0.78 | ALDH1A1 (0.41) | HPGDALDH1A1HTTMMP1MMP2 | |
| SCHEMBL9943963 | 0.76 | ALDH1A1 (0.37) | HPGDALDH1A1HTTMMP1MMP2 | |
| SCHEMBL305560 | 0.76 | ALDH1A1 (0.37) | HPGDALDH1A1HTTMMP1MMP2 | |
| SCHEMBL9019588 | 0.75 | HPGD (0.42) | HPGDALDH1A1HTTMMP1MMP2 | |
| SCHEMBL2575910 | 0.74 | ALDH1A1 (0.41) | HPGDALDH1A1HTTMMP1MMP2 | |
| SCHEMBL1106510 | 0.74 | CHRNB2 (0.46) | HPGDALDH1A1HTTMMP1MMP2 | |
| SCHEMBL9019530 | 0.73 | ALDH1A1 (0.44) | HPGDALDH1A1HTTMMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014100695-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |
| WO-2012052745-A1 | COMBINATIONS OF PI3K INHIBITORS WITH A SECOND ANTI -TUMOR AGENT | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-04-26 | — | — | WO | disclosed |