Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3053533 | 0.83 | MAPT (0.52) | MAPTSMN1; SMN2ALOX15ALDH1A1NPC1 | |
| SCHEMBL5559730 | 0.80 | GAA (0.59) | MAPTSMN1; SMN2ALOX15ALDH1A1NPC1 | |
| SCHEMBL5558780 | 0.73 | CYP2C19 (0.45) | SMN1; SMN2ALDH1A1MTORCYP2C19AKT1 | |
| SCHEMBL6875469 | 0.72 | SMN1; SMN2 (0.40) | MAPTSMN1; SMN2ALOX15ALDH1A1NPC1 | |
| SCHEMBL5558787 | 0.71 | CYP2C19 (0.43) | MAPTALDH1A1MTORCYP1A2CYP2C19 | |
| SCHEMBL5563645 | 0.70 | MAPT (0.35) | MAPTSMN1; SMN2ALOX15NPC1MTOR | |
| SCHEMBL6878390 | 0.70 | MAPT (0.40) | MAPTSMN1; SMN2ALOX15ALDH1A1NPC1 | |
| SCHEMBL11065200 | 0.68 | OPRM1 (0.37) | MAPTALOX15ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL30989601 | 0.68 | KMO (0.51) | MAPTALDH1A1MTORCYP1A2CYP2C19 | |
| SCHEMBL6878049 | 0.66 | ALDH1A1 (0.41) | MAPTSMN1; SMN2ALDH1A1LMNAWNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7273865-B2 | Thiazolopyridine | HOFFMANN-LA ROCHE INC. (US) | 2007-09-25 | — | — | US | disclosed |
| EP-1670805-A1 | THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005028484-A1 | THIAZOLOPYRIDINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-31 | — | — | WO | disclosed |
| US-20050065151-A1 | Thiazolopyridine | HOFFMANN-LA ROCHE INC. | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065151-A1 | Thiazolopyridine | ADORA2A, ADORA3, ADORA1 | MAPT 644/4885SMN1; SMN2 1416/4885ALOX15 2250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.