SCHEMBL5559796

SCHEMBL5559796

CC/C=C/C1=CC(C)(C)COc2cc(Cl)c(F)cc21

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 1/20 0.31
AKR1B1 P15121 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1400074 0.82 NOTUM (0.36) NOTUMAKR1B1
SCHEMBL2317447 0.81 NOTUM (0.37) NOTUMAKR1B1
SCHEMBL2317446 0.81 NOTUM (0.37) NOTUMAKR1B1
SCHEMBL3600626 0.77 RXRA (0.37) NOTUMAKR1B1
SCHEMBL3600621 0.77 RXRA (0.37) NOTUMAKR1B1
SCHEMBL5565147 0.76 HTR1A (0.35)
SCHEMBL5563963 0.75 KCNH2 (0.32)
SCHEMBL5564928 0.72 CHRM5 (0.33)
SCHEMBL5266987 0.72 NOTUM (0.36) NOTUMAKR1B1
SCHEMBL1399897 0.71 CHRM2 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1758876-A1 NEW 5-ALKENONE-3,3-DIMETHYL-BENZOXEPINES DERIVATIVES USEFUL FOR THE PREPARATION OF ANTIDIABETIC PENTADIENOIC ACIDS MERCK PATENT GmbH (DE) 2007-03-07 EP claimed
WO-2006002721-A1 NEW 5-ALKENONE-3,3-DIMETHYL-BENZOXEPINES DERIVATIVES USEFUL FOR THE PREPARATION OF ANTIDIABETIC PENTADIENOIC ACIDS MERCK PATENT GMBH (DE) 2006-01-12 WO claimed
EP-1758876-A1 NEW 5-ALKENONE-3,3-DIMETHYL-BENZOXEPINES DERIVATIVES USEFUL FOR THE PREPARATION OF ANTIDIABETIC PENTADIENOIC ACIDS MERCK PATENT GmbH (DE) 2007-03-07 EP disclosed
WO-2006002721-A1 NEW 5-ALKENONE-3,3-DIMETHYL-BENZOXEPINES DERIVATIVES USEFUL FOR THE PREPARATION OF ANTIDIABETIC PENTADIENOIC ACIDS MERCK PATENT GMBH (DE) 2006-01-12 WO disclosed