Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 6/20 | 0.33 |
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560462 | 1.00 | PTGS2 (0.34) | PTGS2ALOX15GFERADAM17PPARG | |
| SCHEMBL5560554 | 0.88 | HRH3 (0.40) | PTGS2PPARGPPARAAKR1C3AKR1C2 | |
| SCHEMBL5559328 | 0.88 | HRH3 (0.40) | PTGS2PPARGPPARAAKR1C3AKR1C2 | |
| SCHEMBL5798576 | 0.87 | PTGS2 (0.41) | PTGS2PPARGKMT2AKDM4EAKR1C3 | |
| SCHEMBL5554254 | 0.87 | PTGS2 (0.34) | PTGS2KMT2AAKR1C3AKR1C2 | |
| SCHEMBL5559997 | 0.86 | PPARG (0.33) | PTGS2ALOX15GFERADAM17PPARG | |
| SCHEMBL5558485 | 0.84 | PPARG (0.36) | PTGS2PPARGPPARAAKR1C3AKR1C2 | |
| SCHEMBL5558706 | 0.84 | PPARG (0.36) | PTGS2PPARGPPARAAKR1C3AKR1C2 | |
| SCHEMBL5560599 | 0.82 | LMNA (0.39) | KMT2AKDM4EAKR1C3AKR1C2HTT | |
| SCHEMBL5560927 | 0.82 | GAA (0.35) | ALOX15GFERADAM17PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |