Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 12/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5556348 | 0.90 | MTNR1A (0.41) | MTNR1AABCG2MAPTALDH1A1L3MBTL1 | |
| SCHEMBL5562108 | 0.83 | MEN1 (0.48) | MTNR1AABCG2MAPTSLC6A4NPC1 | |
| SCHEMBL5562105 | 0.82 | LMNA (0.44) | MTNR1AABCG2MAPTALDH1A1L3MBTL1 | |
| SCHEMBL5561309 | 0.78 | ALDH1A1 (0.43) | MTNR1AMAPTALDH1A1L3MBTL1SLC6A4 | |
| SCHEMBL5556164 | 0.78 | ALDH1A1 (0.41) | MTNR1AABCG2MAPTALDH1A1L3MBTL1 | |
| SCHEMBL5561871 | 0.75 | GAA (0.47) | MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL5557097 | 0.74 | ALDH1A1 (0.42) | MTNR1AMAPTALDH1A1L3MBTL1NPC1 | |
| SCHEMBL5561821 | 0.74 | MEN1 (0.45) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL5561157 | 0.73 | RAB9A (0.44) | MTNR1AABCG2MAPTALDH1A1L3MBTL1 | |
| SCHEMBL5555430 | 0.73 | GAA (0.44) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631296-B1 | 2,3,4,5-TETRAHYDROBENZO¬F|¬1,4|OXAZEPINE-5-CARBOXYLIC ACID AMIDE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | HOFFMANN LA ROCHE (CH) | 2007-04-25 | — | — | EP | claimed |