Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30437542 | 0.92 | HTR2C (0.53) | HTR2CHTR2AGRIN2BCDK4CCND1 | |
| SCHEMBL8535051 | 0.84 | HTR7 (0.48) | HTR2CHTR2AKCNH2CDK4CCND1 | |
| SCHEMBL14220738 | 0.82 | HTR2A (0.50) | HTR2CHTR2ACNR1CYP1A2CYP2C9 | |
| SCHEMBL23902695 | 0.82 | PRKCI (0.44) | CNR1ACHEHTR6HTR7 | |
| SCHEMBL30365011 | 0.82 | PRKCI (0.44) | CNR1ACHEHTR6HTR7 | |
| SCHEMBL31200469 | 0.81 | TFPI2 (0.46) | HTR2CHTR2ACNR1GRIN2BNPY5R | |
| SCHEMBL22439496 | 0.79 | HTR6 (0.59) | HTR2CHTR2ACDK4CCND1HTR6 | |
| SCHEMBL30292332 | 0.78 | HTR2A (0.52) | HTR2CHTR2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6588850 | 0.78 | ACHE (0.50) | ACHE | |
| SCHEMBL28567591 | 0.77 | ACHE (0.54) | CYP2C9CYP2C19ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7304064-B2 | 1-[(indol-3-yl)carbonyl]piperazine derivatives | N.V. ORGANON (NL) | 2007-12-04 | — | — | US | disclosed |
| EP-1549637-B1 | 1- (INDOL-3-YL)CARBONYL PIPERAZINE DERIVATIVES | ORGANON NV (NL) | 2007-05-02 | — | — | EP | disclosed |
| CN-1298716-C | 1-[(indol-3-yl)carbonyl] piperazine derivatives | AKZO NOBEL NV (NL) | 2007-02-07 | — | — | CN | disclosed |
| US-20050250760-A1 | 1-[(Indol-3-yl)carbonyl]piperazine derivatives | MERCK SHARP & DOHME B.V. (NL) | 2005-11-10 | — | — | US | disclosed |
| CN-1668611-A | 1-[(indol-3-yl)carbonyl] piperazine derivatives | AKZO NOBEL NV (NL) | 2005-09-14 | — | — | CN | disclosed |
| EP-1549637-A1 | 1- (INDOL-3-YL)CARBONYL PIPERAZINE DERIVATIVES | Akzo Nobel N.V. (NL) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004000832-A1 | 1-[(INDOL-3-YL)CARBONYL] PIPERAZINE DERIVATIVES | AKZO NOBEL N.V. (NL) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250760-A1 | 1-[(Indol-3-yl)carbonyl]piperazine derivatives | IDO1, OPRL1, OPRK1 | HTR2C 263/4885HTR2A 466/4885CNR1 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.