Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5565800 | 0.87 | HTT (0.48) | KMT2AALDH1A1HPGDLMNAMAPT | |
| Bromide SCHEMBL5565101 | 0.84 | HTT (0.43) | KMT2AALDH1A1HPGDLMNAMAPT | |
| Bromide SCHEMBL5561271 | 0.81 | CNR2 (0.46) | NPC1ALDH1A1LMNARAB9AMAPT | |
| Bromide SCHEMBL5560141 | 0.81 | MAPT (0.41) | KMT2AMEN1ALDH1A1HPGDLMNA | |
| Bromide SCHEMBL5564744 | 0.81 | CNR2 (0.44) | KMT2AMEN1ALDH1A1CYP2C9CYP1A2 | |
| SCHEMBL6017175 | 0.80 | CNR2 (0.47) | NPC1ALDH1A1LMNARAB9AMAPT | |
| Hydrochloric Acid SCHEMBL5564730 | 0.79 | ALDH1A1 (0.45) | NPC1KMT2AMEN1ALDH1A1CYP2C9 | |
| Bromide SCHEMBL5564610 | 0.79 | ABL1 (0.43) | ALDH1A1MAPTPIK3CAHTT | |
| Bromide SCHEMBL5565311 | 0.78 | HTT (0.41) | KMT2AALDH1A1LMNAMAPTMAPK1 | |
| Bromide SCHEMBL5565848 | 0.78 | CNR2 (0.46) | ALDH1A1CYP2C9CYP1A2LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7300932-B2 | Pyrrolo[1,2-b]pyridazine derivatives | JAPAN TOBACCO INC. (JP) | 2007-11-27 | — | — | US | disclosed |
| EP-1653969-A4 | PYRROLO 1,2-B PYRIDAZINE DERIVATIVES | JAPAN TOBACCO INC (JP) | 2006-12-20 | — | — | EP | disclosed |
| EP-1653969-A2 | PYRROLO 1,2-B PYRIDAZINE DERIVATIVES | Japan Tabacco Inc. (JP) | 2006-05-10 | — | — | EP | disclosed |
| US-20050070545-A1 | For treatment or prevention of metabolic and cell proliferative diseases; modifying lipid metabolism | TULARIK INC. (US) | 2005-03-31 | — | — | US | disclosed |
| WO-2005013907-A2 | PYRROLO[1,2-B]PYRIDAZINE DERIVATIVES | JAPAN TOBACCO INC. (JP) | 2005-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070545-A1 | For treatment or prevention of metabolic and cell proliferative diseases; modifying lipid metabolism | PC, ACACB, ACAT1 | NPC1 172/4885KMT2A 1671/4885MEN1 1029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.