Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.44 |
| ▸ | THRB | P10828 | 10/20 | 0.43 |
| ▸ | THRA | P10827 | 3/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5566905 | 0.94 | MEN1 (0.65) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL5566929 | 0.85 | MEN1 (0.60) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL5995073 | 0.79 | MEN1 (0.69) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL5562109 | 0.79 | MEN1 (0.69) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL9823772 | 0.78 | MEN1 (0.65) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL6342801 | 0.78 | MEN1 (0.71) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL10394519 | 0.78 | MEN1 (0.64) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL9823876 | 0.77 | MEN1 (0.61) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL5565958 | 0.77 | MEN1 (0.61) | MEN1NR1I2KMT2AP2RX7THRB | |
| SCHEMBL10394521 | 0.77 | MEN1 (0.61) | MEN1NR1I2KMT2AP2RX7THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000040-B1 | IL-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2007-06-13 | — | — | EP | disclosed |
| US-6867207-B2 | IL-5 inhibiting 6-azauracil derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-03-15 | — | — | US | disclosed |