Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5568616 | 0.83 | MAPT (0.43) | KDM4EGAAHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL7653260 | 0.72 | PDE5A (0.41) | KDM4EGAAHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL533321 | 0.72 | KDM4E (0.45) | KDM4EGAAHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL5564125 | 0.71 | ACHE (0.41) | KDM4EGAAHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL5565447 | 0.71 | KDM4E (0.44) | KDM4EGAAHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL5567750 | 0.70 | ALDH1A1 (0.49) | KDM4EGAAHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL5568366 | 0.70 | KDM4E (0.42) | KDM4EGAAHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL5568815 | 0.70 | DRD2 (0.51) | KDM4EGAAHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL4838972 | 0.70 | DRD2 (0.51) | KDM4EGAAHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL5568857 | 0.70 | PDE5A (0.43) | KDM4EGAAHSD17B10ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042288-B1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INST NAT SANTE RECH MED (FR) | 2007-11-07 | — | — | EP | disclosed |
| US-6335360-B1 | INDOLINE-2-CARBOXYLIC AMIDE DERIVATIVES; OBESITY, EATING AND PSYCHOLOGICAL DISORDERS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2002-01-01 | — | — | US | disclosed |