Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5568857 | 0.82 | PDE5A (0.43) | PDE5AHSD17B10KDM4EALDH1A1CYP1A2 | |
| SCHEMBL5564125 | 0.75 | ACHE (0.41) | HSD17B10KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL5917429 | 0.75 | PDE5A (0.44) | PDE5AGAAMAPT | |
| SCHEMBL5565447 | 0.75 | KDM4E (0.44) | PDE5AHSD17B10KDM4EALDH1A1CYP1A2 | |
| SCHEMBL29015454 | 0.74 | PDE5A (0.38) | PDE5AHSD17B10KDM4EALDH1A1CYP1A2 | |
| SCHEMBL5567750 | 0.74 | ALDH1A1 (0.49) | PDE5AHSD17B10KDM4EALDH1A1CYP1A2 | |
| SCHEMBL5567865 | 0.74 | PDE5A (0.39) | PDE5AGAAMAPTKMT2A | |
| SCHEMBL5568815 | 0.73 | DRD2 (0.51) | HSD17B10KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL5568366 | 0.73 | KDM4E (0.42) | PDE5AHSD17B10KDM4EALDH1A1CYP1A2 | |
| SCHEMBL3256076 | 0.73 | PDE5A (0.41) | PDE5AALDH1A1GAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6335360-B1 | INDOLINE-2-CARBOXYLIC AMIDE DERIVATIVES; OBESITY, EATING AND PSYCHOLOGICAL DISORDERS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2002-01-01 | — | — | US | disclosed |
| EP-1042288-A1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033801-A1 | TRIPEPTIDYL PEPTIDASE INHIBITORS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1999-07-08 | — | — | WO | disclosed |