Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.38 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5572186 | 0.85 | BDKRB2 (0.39) | CRHR1BDKRB2ADORA2AHCRTR1HCRTR2 | |
| SCHEMBL5572013 | 0.83 | BDKRB2 (0.38) | CRHR1BDKRB2ADORA2AHCRTR1HCRTR2 | |
| SCHEMBL5571874 | 0.83 | CRHR1 (0.40) | CRHR1BDKRB2ADORA2AHCRTR1HCRTR2 | |
| SCHEMBL5572225 | 0.77 | GRM5 (0.38) | CRHR1F10MAPK1 | |
| SCHEMBL5572302 | 0.76 | HCRTR1 (0.40) | CRHR1BDKRB2HCRTR1HCRTR2KDM4E | |
| SCHEMBL5572296 | 0.75 | CRHR1 (0.37) | CRHR1BDKRB2ADORA2AF10KDM4E | |
| SCHEMBL5572298 | 0.75 | CRHR1 (0.37) | CRHR1BDKRB2ADORA2AF10KDM4E | |
| SCHEMBL3244939 | 0.74 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL2192145 | 0.70 | CRHR1 (0.47) | CRHR1ALDH1A1 | |
| SCHEMBL14601148 | 0.67 | CRHR1 (0.54) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070066640-A1 | Heteroaryl-substituted pyrrolo'2,3-b1 pyridine derivatives as crf receptor antagonists | SMITHKLINE BEECHAM (CORK) LIMITED (IE) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066640-A1 | Heteroaryl-substituted pyrrolo'2,3-b1 pyridine derivatives as crf receptor antagonists | CRHR1, CRHR2, CRH | CRHR1 1/4885BDKRB2 34/4885ADORA2A 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.