Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5572298 | 0.84 | CRHR1 (0.37) | CRHR1KDM4EALDH1A1BDKRB2F10 | |
| SCHEMBL5572296 | 0.84 | CRHR1 (0.37) | CRHR1KDM4EALDH1A1BDKRB2F10 | |
| SCHEMBL5568709 | 0.83 | CRHR1 (0.38) | CRHR1KDM4EALDH1A1MAPK1BDKRB2 | |
| SCHEMBL5572186 | 0.79 | BDKRB2 (0.39) | CRHR1KDM4EALDH1A1MAPTBDKRB2 | |
| SCHEMBL5572013 | 0.77 | BDKRB2 (0.38) | CRHR1KDM4EALDH1A1MAPTBDKRB2 | |
| SCHEMBL5572302 | 0.76 | HCRTR1 (0.40) | CRHR1KDM4EALDH1A1BDKRB2HCRTR1 | |
| SCHEMBL5572219 | 0.76 | GRM5 (0.40) | CRHR1KDM4EMAPK1MAPTNPSR1 | |
| SCHEMBL14601148 | 0.71 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL2188954 | 0.68 | CRHR1 (0.48) | CRHR1ALDH1A1NPSR1 | |
| SCHEMBL2630762 | 0.65 | ALDH1A1 (0.41) | KDM4EALDH1A1MAPK1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070066640-A1 | Heteroaryl-substituted pyrrolo'2,3-b1 pyridine derivatives as crf receptor antagonists | SMITHKLINE BEECHAM (CORK) LIMITED (IE) | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066640-A1 | Heteroaryl-substituted pyrrolo'2,3-b1 pyridine derivatives as crf receptor antagonists | CRHR1, CRHR2, CRH | CRHR1 1/4885KDM4E 4352/4885ALDH1A1 2319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.