Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11530910 | 0.85 | KDM4E (0.46) | CA2KDM4EALDH1A1TBXA2RLMNA | |
| SCHEMBL11531134 | 0.81 | ALDH1A1 (0.49) | ALDH1A1TBXA2R | |
| SCHEMBL15338335 | 0.77 | HTR2A (0.44) | — | |
| SCHEMBL16526945 | 0.75 | MAPK8 (0.54) | CA2ALDH1A1LMNA | |
| SCHEMBL11862393 | 0.75 | ACHE (0.58) | CA2 | |
| SCHEMBL658778 | 0.74 | MAPK8 (0.55) | CA2ALDH1A1LMNA | |
| SCHEMBL31339549 | 0.74 | MAPK8 (0.55) | CA2ALDH1A1LMNA | |
| SCHEMBL3800131 | 0.72 | CA2 (0.46) | CA2KDM4EALDH1A1LMNAPOLB | |
| SCHEMBL24997114 | 0.72 | CTSD (0.42) | SLC6A2SLC6A4 | |
| SCHEMBL9472297 | 0.71 | CA2 (0.47) | CA2KDM4EALDH1A1TBXA2RLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866292-A1 | TRICYCLIC 1,2,4-TRIAZINE OXIDES AND COMPOSITIONS THEREFROM FOR THERAPEUTIC USE IN CANCER TREATMENTS | Auckland Uniservices Limited (NZ) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006104406-A1 | TRICYCLIC 1,2,4-TRIAZINE OXIDES AND COMPOSITIONS THEREFROM FOR THERAPEUTIC USE IN CANCER TREATMENTS | AUCKLAND UNISERVICES LIMITED (NZ) | 2006-10-05 | — | — | WO | disclosed |