Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.60 |
| ▸ | PPARA | Q07869 | 2/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.47 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.47 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 3/20 | 0.42 |
| ▸ | RARA | P10276 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5595846 | 0.85 | BACE1 (0.72) | KAT8BACE1HSP90AA1HSP90AB1HSD17B1 | |
| SCHEMBL254346 | 0.83 | KAT8 (0.54) | KAT8PPARALCKEGFRKLKB1 | |
| SCHEMBL5569783 | 0.83 | KAT8 (0.57) | KAT8PPARALCKEGFRKLKB1 | |
| SCHEMBL6386713 | 0.81 | KAT8 (0.49) | KAT8PPARALCKPPARG | |
| SCHEMBL5569389 | 0.81 | BACE1 (0.51) | KAT8PPARABACE1LCKEGFR | |
| SCHEMBL1356365 | 0.80 | KAT8 (0.66) | KAT8PPARAPPARGRARBRARA | |
| SCHEMBL11328457 | 0.80 | BACE1 (0.70) | KAT8PPARABACE1HSP90AA1HSP90AB1 | |
| SCHEMBL3033028 | 0.79 | KAT8 (0.73) | KAT8PPARAPPARGRARBRARA | |
| SCHEMBL1023618 | 0.79 | BACE1 (0.68) | KAT8PPARABACE1HSP90AA1HSP90AB1 | |
| SCHEMBL2687820 | 0.78 | KAT8 (0.62) | KAT8PPARALCKEGFRKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312249-B2 | Vitamin D analogues | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2007-12-25 | — | — | US | disclosed |
| EP-1537065-B1 | ANALOGUES OF VITAMIN D | GALDERMA RES & DEV (FR) | 2006-11-02 | — | — | EP | disclosed |
| US-20050182144-A1 | Novel vitamin D analogues | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182144-A1 | Novel vitamin D analogues | CYP24A1, CYP2R1, VDR | KAT8 4452/4885PPARA 134/4885BACE1 1060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.