Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.57 |
| ▸ | PPARA | Q07869 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.49 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.49 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.49 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.46 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.46 |
| ▸ | RARB | P10826 | 1/20 | 0.46 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL254346 | 0.85 | KAT8 (0.54) | KAT8PPARALCKKLKB1CTSB | |
| SCHEMBL5570240 | 0.83 | KAT8 (0.60) | KAT8PPARALCKKLKB1CTSB | |
| SCHEMBL529618 | 0.83 | ESR1 (0.68) | ESR1ESR2IGF1RALOX15 | |
| SCHEMBL5565669 | 0.81 | ESR1 (0.45) | KAT8PPARAESR1ESR2IGF1R | |
| SCHEMBL8159417 | 0.79 | KAT8 (0.62) | KAT8PPARALCKKLKB1CTSB | |
| SCHEMBL2687820 | 0.79 | KAT8 (0.62) | KAT8PPARALCKKLKB1CTSB | |
| SCHEMBL68664 | 0.79 | ESR1 (0.68) | KAT8ESR1ESR2IGF1RALOX15 | |
| SCHEMBL27918636 | 0.79 | CYP1A2 (0.54) | KAT8ESR1ESR2IGF1RALOX15 | |
| SCHEMBL23265352 | 0.79 | KLKB1 (0.79) | KAT8LCKKLKB1CTSBMMP9 | |
| SCHEMBL7071495 | 0.78 | HDAC1 (0.50) | KAT8PPARALCKHNF4AIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312249-B2 | Vitamin D analogues | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2007-12-25 | — | — | US | disclosed |
| US-20050182144-A1 | Novel vitamin D analogues | GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182144-A1 | Novel vitamin D analogues | CYP24A1, CYP2R1, VDR | KAT8 4452/4885PPARA 134/4885LCK 4855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.