SCHEMBL5570859

SCHEMBL5570859

Cc1c(N2C(=O)C=CC2=O)c(=O)oc2cc(N(C)C)ccc12.O=C1C=CC(=O)N1c1ccc(-c2nc3ccccc3[nH]2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EP300 Q09472 1/20 0.49
CCR4 P51679 1/20 0.43
NPC1 O15118 7/20 0.42
RAB9A P51151 7/20 0.42
MAPT P10636 4/20 0.42
MEN1 O00255 2/20 0.42
POLB P06746 2/20 0.42
KMT2A Q03164 2/20 0.42
USP2 O75604 1/20 0.42
LMNA P02545 1/20 0.42
TP53 P04637 1/20 0.42
CASP1 P29466 1/20 0.42
BRCA1 P38398 1/20 0.42
HTT P42858 1/20 0.42
CASP7 P55210 1/20 0.42
HBB P68871 1/20 0.42
ATM Q13315 1/20 0.42
PTK2B Q14289 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
KDM4E B2RXH2 5/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5570862 0.87 NPC1 (0.41) EP300NPC1RAB9AMAPTMEN1
SCHEMBL179796 0.79 CCR4 (0.64) EP300CCR4MAPTMEN1KMT2A
SCHEMBL29527262 0.79 CCR4 (0.64) EP300CCR4MAPTMEN1KMT2A
SCHEMBL179732 0.75 NPC1 (0.58) NPC1RAB9AMAPTPOLBKMT2A
SCHEMBL7750137 0.75 EP300 (0.78) EP300CCR4NPC1RAB9AMAPT
SCHEMBL3363523 0.69 EP300 (0.69) EP300CCR4MAPTMEN1KMT2A
SCHEMBL30349923 0.69 MAPT (0.80) NPC1RAB9AMAPTMEN1POLB
SCHEMBL4494231 0.69 MAPT (0.80) NPC1RAB9AMAPTMEN1POLB
SCHEMBL60856 0.68 AURKA (0.66) NPC1RAB9AMAPTMEN1POLB
SCHEMBL30601531 0.68 NPC1 (0.51) NPC1RAB9AMAPTPOLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7282327-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2007-10-16 US claimed