Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 3/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | MMP15 | P51511 | 1/20 | 0.44 |
| ▸ | MMP16 | P51512 | 1/20 | 0.44 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.44 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.43 |
| ▸ | VCP | P55072 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6516727 | 0.80 | VCP (0.63) | APPMAPTVCP | |
| SCHEMBL400497 | 0.78 | MAPT (0.59) | APPMAPTGRM5MMP2MMP9 | |
| SCHEMBL608234 | 0.78 | — | — | |
| SCHEMBL2114741 | 0.75 | APP (0.92) | APPMAPTGRM5FFAR1KCNH2 | |
| SCHEMBL30108319 | 0.75 | APP (0.60) | APPMAPTGRM5MMP2MMP9 | |
| SCHEMBL3656317 | 0.75 | SMN1; SMN2 (0.60) | MAPT | |
| SCHEMBL7732264 | 0.74 | MAPT (0.70) | APPMAPTGRM5MMP2MMP9 | |
| SCHEMBL402518 | 0.73 | RARB (0.62) | APPGRM5MMP2MMP9MMP12 | |
| SCHEMBL1272448 | 0.73 | HDAC8 (0.39) | — | |
| SCHEMBL28879880 | 0.73 | CA2 (0.50) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7180308-B2 | Screening for electrical conductivity of molecules by measuring surface potential | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-02-20 | — | — | US | disclosed |
| US-20040245980-A1 | Screening for electrical conductivity of molecules by measuring surface potential | E. I. DU PONT DE NEMOURS AND COMPANY | 2004-12-09 | — | — | US | disclosed |