Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | CASP7 | P55210 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3805823 | 0.73 | GPR3 (0.42) | GPR3CYP1A2CYP2C19KDM4EALDH1A1 | |
| SCHEMBL15833936 | 0.73 | GPR3 (0.42) | GPR3CYP1A2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL4025561 | 0.71 | KDM4E (0.45) | GPR3CYP1A2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL11877290 | 0.71 | GPR3 (0.40) | GPR3CYP1A2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL11085745 | 0.71 | MAOA (0.44) | GPR3CYP1A2CYP2C19KDM4EALDH1A1 | |
| SCHEMBL12799106 | 0.71 | GPR3 (0.41) | GPR3CYP1A2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL23495082 | 0.71 | KDM4E (0.38) | CYP1A2CYP2C19KDM4EALDH1A1MAPT | |
| SCHEMBL21658663 | 0.71 | AKR1B1 (0.40) | GPR3KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL15758027 | 0.71 | AKR1B1 (0.43) | GPR3CYP1A2CYP2C19KDM4EALDH1A1 | |
| SCHEMBL18160956 | 0.68 | ADORA2A (0.39) | GPR3CYP1A2CYP2C19KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044325-A1 | FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX | CLEAVE BIOSCIENCES, INC. | 2018-02-15 | — | — | US | disclosed |
| US-9828363-B2 | Fused pyrimidines as inhibitors of P97 complex | CLEAVE BIOSCIENCES, INC. (US) | 2017-11-28 | — | — | US | disclosed |
| US-20160355503-A1 | NITROGEN HEXACYCLE COMPOUNDS AS INHIBITORS OF p97 COMPLEX | CLEAVE BIOSCIENCES, INC. | 2016-12-08 | — | — | US | disclosed |
| US-20160332990-A1 | FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX | CLEAVE BIOSCIENCES, INC. (US) | 2016-11-17 | — | — | US | disclosed |
| EP-1778639-A2 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR Technology, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1660427-A4 | SUBSTITUTED ARYLALKANOIC ACID DERIVATIVE AND USE THEREOF | ASAHI KASEI PHARMA CORP (JP) | 2006-12-20 | — | — | EP | disclosed |
| EP-1660427-A1 | SUBSTITUTED ARYLALKANOIC ACID DERIVATIVE AND USE THEREOF | Asahi Kasei Pharma Corporation (JP) | 2006-05-31 | — | — | EP | disclosed |
| WO-2006020049-A2 | ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN | AMR TECHNOLOGY, INC. (US) | 2006-02-23 | — | — | WO | disclosed |
| WO-2005016862-A1 | SUBSTITUTED ARYLALKANOIC ACID DERIVATIVE AND USE THEREOF | ASAHI KASEI PHARMA CORPORATION (JP) | 2005-02-24 | — | — | WO | disclosed |
| EP-0751943-A1 | TRIAZOLE COMPOUNDS AND PROCESSES FOR THE PREPARATION THEREOF | Yuhan Corporation (KR) | 1997-01-08 | — | — | EP | disclosed |
| WO-1995025107-A1 | TRIAZOLE COMPOUNDS AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORPORATION (KR) | 1995-09-21 | — | — | WO | disclosed |
| US-4087420-A | DYEING AND PRINTING OF HYDROPHOBIC SYNTHETIC FIBERS AND FILMS | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) | 1978-05-02 | — | — | US | disclosed |
| US-4035143-A | HYDROPHOBIC FIBERS AND FILMS, HETEROAROMATIC RADICALS | CASSELLA FARBWERKE MAINKUR AKTIENGESELLSCHAFT (DT) | 1977-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160332990-A1 | FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX | WDR77, POP1, PSMG3 | GPR3 3198/4885CYP1A2 2931/4885CYP2C19 3981/4885 |
| US-20180044325-A1 | FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX | WDR77, POP1, PSMG3 | GPR3 3208/4885CYP1A2 2890/4885CYP2C19 3946/4885 |
| US-20160355503-A1 | NITROGEN HEXACYCLE COMPOUNDS AS INHIBITORS OF p97 COMPLEX | PSMG3, PSME1, PSME2 | GPR3 3337/4885CYP1A2 2609/4885CYP2C19 3530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.