Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.30 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9178986 | 0.90 | KDM4E (0.39) | CA2HTTSLC6A4KDM4EL3MBTL1 | |
| SCHEMBL9563491 | 0.82 | TAAR1 (0.43) | HTTSLC6A4KDM4ECHRM2CHRM1 | |
| SCHEMBL9563493 | 0.82 | TAAR1 (0.43) | HTTSLC6A4KDM4ECHRM2CHRM1 | |
| SCHEMBL1741422 | 0.80 | CA2 (0.35) | CA2SLC6A4L3MBTL1CACNA1FCHRM2 | |
| SCHEMBL9179086 | 0.79 | ADRB2 (0.38) | MKNK1CACNA1FCHRM2CHRM1ADRA2B | |
| SCHEMBL9179092 | 0.79 | ADRB2 (0.38) | MKNK1CACNA1FCHRM2CHRM1ADRA2B | |
| SCHEMBL3386536 | 0.75 | TAAR1 (0.41) | CA2SLC6A4SLC6A3 | |
| SCHEMBL3386535 | 0.75 | TAAR1 (0.41) | CA2SLC6A4SLC6A3 | |
| SCHEMBL3386613 | 0.75 | TAAR1 (0.41) | CA2SLC6A4SLC6A3 | |
| SCHEMBL1739510 | 0.75 | GSR (0.44) | CA2SLC6A4L3MBTL1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786773-A1 | ISOINDOLIN-1-ONE DERIVATIVES | Cancer Research Technology Limited (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024837-A1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |