Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 16/20 | 0.56 |
| ▸ | NOS3 | P29474 | 12/20 | 0.56 |
| ▸ | NOS2 | P35228 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221161 | 0.86 | NOS1 (0.57) | NOS1NOS3NOS2ALDH1A1 | |
| SCHEMBL252141 | 0.84 | NOS1 (0.79) | NOS1NOS3NOS2ALDH1A1 | |
| SCHEMBL219308 | 0.77 | NOS1 (0.55) | NOS1NOS3ALDH1A1 | |
| SCHEMBL4014224 | 0.77 | NOS1 (0.50) | NOS1NOS3NOS2 | |
| SCHEMBL4858606 | 0.76 | NOS3 (0.47) | NOS1NOS3NOS2ALDH1A1 | |
| SCHEMBL421876 | 0.76 | NOS1 (0.57) | NOS1NOS3NOS2 | |
| SCHEMBL7080400 | 0.75 | NOS1 (0.68) | NOS1NOS3NOS2 | |
| SCHEMBL14265508 | 0.72 | NOS1 (0.74) | NOS1NOS3NOS2 | |
| SCHEMBL250986 | 0.72 | NOS1 (1.00) | NOS1NOS3NOS2ALDH1A1 | |
| SCHEMBL4858610 | 0.71 | MCHR1 (0.44) | NOS1NOS3NOS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856099-A2 | ACRIDINE AND QUINOLINE DERIVATIVES AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006094237-A2 | ACRIDINE AND QUINOLINE DERVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2006-09-08 | — | — | WO | disclosed |