Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 7/20 | 0.47 |
| ▸ | NOS1 | P29475 | 7/20 | 0.47 |
| ▸ | NOS2 | P35228 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221161 | 0.90 | NOS1 (0.57) | NOS3NOS1NOS2KDM4EALDH1A1 | |
| SCHEMBL4858610 | 0.83 | MCHR1 (0.44) | NOS3NOS1NOS2KDM4EALDH1A1 | |
| SCHEMBL27981558 | 0.81 | KDM4E (0.44) | NOS3NOS1NOS2KDM4EALDH1A1 | |
| SCHEMBL7080400 | 0.79 | NOS1 (0.68) | NOS3NOS1NOS2MCHR1POLB | |
| SCHEMBL5572479 | 0.76 | NOS1 (0.56) | NOS3NOS1NOS2ALDH1A1 | |
| SCHEMBL4858622 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1MCHR1POLBHTR2C | |
| SCHEMBL252141 | 0.72 | NOS1 (0.79) | NOS3NOS1NOS2KDM4EALDH1A1 | |
| SCHEMBL4014224 | 0.71 | NOS1 (0.50) | NOS3NOS1NOS2 | |
| SCHEMBL221914 | 0.70 | NOS3 (0.63) | NOS3NOS1NOS2KDM4EALDH1A1 | |
| SCHEMBL421876 | 0.69 | NOS1 (0.57) | NOS3NOS1NOS2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910362-A1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019345-A1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |