Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 9/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221161 | 0.84 | NOS1 (0.57) | MCHR1KDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL4858606 | 0.83 | NOS3 (0.47) | MCHR1KDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL5823660 | 0.83 | CDK2 (0.39) | KDM4ECDK2CDK9CDK5NOS3 | |
| SCHEMBL27981558 | 0.79 | KDM4E (0.44) | MCHR1KDM4EALDH1A1NOS3NOS1 | |
| SCHEMBL4858622 | 0.79 | KDM4E (0.43) | MCHR1KDM4EALDH1A1BCHEACHE | |
| SCHEMBL7080400 | 0.73 | NOS1 (0.68) | MCHR1NOS3NOS1NOS2POLB | |
| SCHEMBL5572479 | 0.71 | NOS1 (0.56) | ALDH1A1NOS3NOS1NOS2 | |
| SCHEMBL252141 | 0.66 | NOS1 (0.79) | KDM4EALDH1A1NOS3NOS1NOS2 | |
| SCHEMBL19219203 | 0.66 | CDK9 (0.57) | KDM4EALDH1A1CDK2CDK9CDK5 | |
| SCHEMBL4014224 | 0.66 | NOS1 (0.50) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910362-A1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019345-A1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |