Sugi Predict

Sugi Predict / Compounds / SCHEMBL5572841

SCHEMBL5572841

SCHEMBL5572841

Cc1c(Br)ccc2nccn12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CDK8 P49336 2/20 0.41
▸ ROCK1 Q13464 2/20 0.41
▸ FLT1 P17948 1/20 0.41
▸ CDK9 P50750 1/20 0.41
▸ LIMK1 P53667 1/20 0.41
▸ CLK4 Q9HAZ1 1/20 0.41
▸ DYRK1A Q13627 3/20 0.38
▸ CHEK1 O14757 1/20 0.38
▸ MAP4K4 O95819 1/20 0.38
▸ CSF1R P07333 1/20 0.38
▸ PRKACA P17612 1/20 0.38
▸ KDR P35968 1/20 0.38
▸ MAP2K1 Q02750 1/20 0.38
▸ ACVR1 Q04771 1/20 0.38
▸ MAP4K2 Q12851 1/20 0.38
▸ AURKB Q96GD4 1/20 0.38
▸ DYRK1B Q9Y463 1/20 0.38
▸ IDO1 P14902 2/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ NPC1 O15118 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27385858 0.80 CDK8 (0.41) CDK8ROCK1FLT1CDK9LIMK1
SCHEMBL17174248 0.79 CDK8 (0.47) CDK8ROCK1FLT1CDK9LIMK1
SCHEMBL21657679 0.77 CDK8 (0.39) CDK8ROCK1FLT1CDK9LIMK1
SCHEMBL15688160 0.76 CDK8 (0.45) CDK8ROCK1FLT1CDK9LIMK1
SCHEMBL3187668 0.76 CDK8 (0.41) CDK8ROCK1FLT1CDK9LIMK1
SCHEMBL19510399 0.76 CDK8 (0.41) CDK8ROCK1FLT1CDK9LIMK1
SCHEMBL18319487 0.76 DYRK1A (0.38) CDK8ROCK1FLT1CDK9LIMK1
SCHEMBL25347661 0.76 CDK8 (0.35) CDK8ROCK1FLT1CDK9LIMK1
SCHEMBL17812868 0.73 CDK8 (0.39) CDK8ROCK1FLT1CDK9LIMK1
SCHEMBL19510491 0.73 ROCK1 (0.39) CDK8ROCK1FLT1CDK9LIMK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12448392-B2 Spiropiperidine derivatives CEPHALON LLC (US) 2025-10-21 — — US disclosed
US-12441702-B2 Substituted 4-benzyl and 4-benzoyl piperidine derivates CEPHALON LLC (US) 2025-10-14 — — US disclosed
US-20250304558-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF EPILEPSY OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2025-10-02 — — US disclosed
US-12391674-B2 Heterocyclic compounds for the treatment of epilepsy OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2025-08-19 — — US disclosed
US-20250257035-A1 1,4-Substituted Piperidine Derivatives CEPHALON LLC 2025-08-14 — — US disclosed
US-12098130-B2 1,4-substituted piperidine derivatives 89BIO LTD (IL) 2024-09-24 — — US disclosed
EP-3845546-B1 COMPLEXES JOHNSON MATTHEY PLC (GB) 2024-06-19 — — EP disclosed
EP-3842421-B1 COMPLEXES JOHNSON MATTHEY PLC (GB) 2024-06-12 — — EP disclosed
CN-118139862-A Nitrogen-containing heterocyclic compound and medical application thereof 中国医药研究开发中心有限公司 2024-06-04 — — CN disclosed
US-20240166661-A1 Spiropiperidine Derivatives CEPHALON LLC 2024-05-23 — — US disclosed
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON LLC 2016-12-22 — — US disclosed
WO-2016205633-A1 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES CEPHALON, INC. (US) 2016-12-22 — — WO disclosed
WO-2015189554-A1 COMPLEXES JOHNSON MATTHEY PUBLIC LIMITED COMPANY (GB) 2015-12-17 — — WO disclosed
US-20070066624-A1 Chemokine receptor binding compounds ANORMED, INC. (CA) 2007-03-22 — — US disclosed
EP-0199127-B1 5-(6-imidazo[1,2-a]pyridyl) pyridine derivative Eisai Co., Ltd. (JP) 1989-12-13 — — EP disclosed
US-4803276-A CARDIOTONIC AGENTS, VASODILATION EISAI CO., LTD. (JP) 1989-02-07 — — US disclosed
US-4791202-A CARDIOTONIC AGENTS; CONGESTIVE HEART FAILURE EISAI CO., LTD. (JP) 1988-12-13 — — US disclosed
US-4791203-A CARDIOTONIC AGENTS EISAI CO., LTD. (JP) 1988-12-13 — — US disclosed
US-4751227-A 3-cyano-5-(6-imidazo[1,2-a]pyridyl)pyridin-2-ols useful as cardiotonics EISAI CO., LTD. (JP) 1988-06-14 — — US disclosed
EP-0199127-A1 5-(6-imidazo[1,2-a]pyridyl) pyridine derivative Eisai Co., Ltd. (JP) 1986-10-29 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250257035-A1 1,4-Substituted Piperidine Derivatives FASN, CES1, CPT1A CDK8 3352/4885ROCK1 2370/4885FLT1 966/4885
US-12441702-B2 Substituted 4-benzyl and 4-benzoyl piperidine derivates FASN, CES1, FADS2 CDK8 3454/4885ROCK1 3189/4885FLT1 1079/4885
US-12391674-B2 Heterocyclic compounds for the treatment of epilepsy SLC6A11, SCN1A, SCN1B CDK8 933/4885ROCK1 2090/4885FLT1 2031/4885
US-20160368874-A1 1,4-SUBSTITUTED PIPERIDINE DERIVATIVES FASN, CES1, CPT1A CDK8 3352/4885ROCK1 2370/4885FLT1 966/4885
US-12448392-B2 Spiropiperidine derivatives FASN, FADS2, SCD5 CDK8 3975/4885ROCK1 1810/4885FLT1 1946/4885
US-20070066624-A1 Chemokine receptor binding compounds CCR5, CCR4, CCR1 CDK8 878/4885ROCK1 1650/4885FLT1 1253/4885
US-20240166661-A1 Spiropiperidine Derivatives FASN, FADS2, SCD5 CDK8 3975/4885ROCK1 1810/4885FLT1 1946/4885
US-12098130-B2 1,4-substituted piperidine derivatives FASN, CES1, CPT1A CDK8 3352/4885ROCK1 2370/4885FLT1 966/4885
US-20250304558-A1 HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF EPILEPSY SLC6A11, SCN1A, KCNH1 CDK8 983/4885ROCK1 1795/4885FLT1 2323/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.