SCHEMBL5576902

SCHEMBL5576902

COc1ccc(C(OCCCCCC(O)C(O)CCCCC(C)(C)[Si](O)(c2ccccc2)c2ccccc2)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC6A11 P48066 5/20 0.38
SLC6A1 P30531 2/20 0.38
KIF11 P52732 5/20 0.36
KCNH2 Q12809 1/20 0.36
MEN1 O00255 1/20 0.34
TP53 P04637 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
KMT2A Q03164 1/20 0.34
SLC6A12 P48065 1/20 0.34
SLC6A13 Q9NSD5 1/20 0.34
LTB4R Q15722 1/20 0.32
TK2 O00142 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5576662 0.87 SLC6A11 (0.37) SLC6A11SLC6A1KIF11KCNH2MEN1
SCHEMBL14959857 0.83 SLC6A11 (0.39) SLC6A11SLC6A1KIF11KCNH2MEN1
SCHEMBL887495 0.82 SLC6A11 (0.40) SLC6A11SLC6A1KIF11KCNH2MEN1
SCHEMBL2631346 0.82 SLC6A11 (0.43) SLC6A11SLC6A1KIF11KCNH2MEN1
SCHEMBL13778535 0.77 RIPK1 (0.34)
SCHEMBL4428713 0.76 SLC6A11 (0.44) SLC6A11SLC6A1KIF11KCNH2MEN1
SCHEMBL4422401 0.76 SLC6A11 (0.44) SLC6A11SLC6A1KIF11KCNH2MEN1
SCHEMBL6849984 0.73 SLC6A11 (0.46) SLC6A11SLC6A1KIF11KCNH2MEN1
SCHEMBL887485 0.73 SLC6A11 (0.46) SLC6A11SLC6A1KIF11KCNH2MEN1
SCHEMBL27051202 0.73 SLC6A11 (0.46) SLC6A11SLC6A1KIF11KCNH2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170021325-A1 Preparation of Templates for Nucleic Acid Sequencing SOLEXA LIMITED (GB) 2017-01-26 US disclosed
US-9512478-B2 Methods for indexing samples and sequencing multiple polynucleotide templates ILLUMINA CAMBRIDGE LIMITED (GB) 2016-12-06 US disclosed
US-9498763-B2 Preparation of templates for nucleic acid sequencing ILLUMINA CAMBRIDGE LIMITED (GB) 2016-11-22 US disclosed
US-20160090623-A1 METHOD FOR PAIRWISE SEQUENCING OF TARGET POLYNUCLEOTIDES ILLUMINA CAMBRIDGE LIMITED (GB) 2016-03-31 US disclosed
US-9267173-B2 Method for pairwise sequencing of target polynucleotides ILLUMINA CAMBRIDGE LIMITED (GB) 2016-02-23 US disclosed
US-20150343410-A1 Preparation of Templates for Nucleic Acid Sequencing ILLUMINA CAMBRIDGE LIMITED (GB) 2015-12-03 US disclosed
US-9085802-B2 Preparation of templates for nucleic acid sequencing ILLUMINA CAMBRIDGE LIMITED (GB) 2015-07-21 US disclosed
US-20140349891-A1 Preparation of Templates for Nucleic Acid Sequencing ILLUMINA CAMBRIDGE LIMITED (GB) 2014-11-27 US disclosed
US-20140336057-A1 METHOD FOR PAIRWISE SEQUENCING OF TARGET POLYNUCLEOTIDES ILLUMINA CAMBRIDGE LIMITED (GB) 2014-11-13 US disclosed
US-20140329698-A1 METHODS FOR INDEXING SAMPLES AND SEQUENCING MULTIPLE POLYNUCLEOTIDE TEMPLATES ILLUMINA CAMBRIDGE LIMITED (GB) 2014-11-06 US disclosed
US-8822150-B2 Methods for indexing samples and sequencing multiple polynucleotide templates ILLUMINA CAMBRIDGE LIMITED (GB) 2014-09-02 US disclosed
EP-2084295-B1 METHOD FOR SEQUENCING A POLYNUCLEOTIDE TEMPLATE ILLUMINA CAMBRIDGE LTD (GB) 2013-05-22 EP disclosed
US-8431348-B2 Method for pairwise sequencing of target polynucleotides ILLUMINA CAMBRIDGE LIMITED (GB) 2013-04-30 US disclosed
US-20120316072-A1 Methods for indexing samples and sequencing multiple polynucleotide templates ILLUMINA CAMBRIDGE LIMITED (GB) 2012-12-13 US disclosed
EP-1910559-B1 PREPARATION OF TEMPLATES FOR NUCLEIC ACID SEQUENCING ILLUMINA CAMBRIDGE LTD (GB) 2012-06-13 EP disclosed
EP-2453023-A2 Method for sequencing a polynucleotide template Illumina Cambridge Limited (GB) 2012-05-16 EP disclosed
WO-2008093098-A2 METHODS FOR INDEXING SAMPLES AND SEQUENCING MULTIPLE NUCLEOTIDE TEMPLATES ILLUMINA CAMBRIDGE LIMITED (GB) 2008-08-07 WO disclosed
WO-2008041002-A2 METHOD FOR SEQUENCING A POLYNUCLEOTIDE TEMPLATE ILLUMINA CAMBRIDGE LIMITED (GB) 2008-04-10 WO disclosed
WO-2007010251-A2 PREPARATION OF TEMPLATES FOR NUCLEIC ACID SEQUENCING SOLEXA LIMITED (GB) 2007-01-25 WO disclosed