Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.55 |
| ▸ | PPARA | Q07869 | 2/20 | 0.55 |
| ▸ | PPARG | P37231 | 12/20 | 0.53 |
| ▸ | RXRA | P19793 | 1/20 | 0.53 |
| ▸ | MPC2 | O95563 | 2/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ciglitazone SCHEMBL20125576 | 0.84 | HPGD (1.00) | CYP3A4MAPTMEN1ALDH1A1TP53 | |
| Ciglitazone SCHEMBL20125581 | 0.84 | HPGD (1.00) | CYP3A4MAPTMEN1ALDH1A1TP53 | |
| Ciglitazone SCHEMBL38185 | 0.84 | HPGD (1.00) | CYP3A4MAPTMEN1ALDH1A1TP53 | |
| Ciglitazone SCHEMBL21582134 | 0.83 | HPGD (0.98) | CYP3A4MAPTMEN1ALDH1A1TP53 | |
| Ciglitazone SCHEMBL3189397 | 0.83 | HPGD (0.98) | CYP3A4MAPTMEN1ALDH1A1TP53 | |
| SCHEMBL12521809 | 0.82 | CYP3A4 (0.76) | CYP3A4MAPTMEN1ALDH1A1TP53 | |
| SCHEMBL9570670 | 0.80 | FFAR1 (0.71) | CYP3A4MAPTMEN1ALDH1A1TP53 | |
| SCHEMBL8957475 | 0.79 | MAPT (0.68) | CYP3A4MAPTMEN1ALDH1A1TP53 | |
| Ciglitazone SCHEMBL8498957 | 0.79 | HPGD (0.89) | CYP3A4MAPTMEN1ALDH1A1TP53 | |
| SCHEMBL14524702 | 0.79 | HRH3 (0.64) | CYP3A4MAPTMEN1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070093536-A1 | Target protein of antidiabetic and novel antidiabetic insuful corresponding thereto | REVERSE PROTEOMICS RESEARCH INSTITUTE CO., LTD. (JP) | 2007-04-26 | — | — | US | claimed |
| EP-1698696-A1 | TARGET PROTEIN OF ANTIDIABETIC AGENT AND NOVEL ANTIDIABETIC AGENT INSUFUL CORRESPONDING THERETO | Reverse Proteomics Research Institute Co., Ltd (JP) | 2006-09-06 | — | — | EP | claimed |
| US-20070093536-A1 | Target protein of antidiabetic and novel antidiabetic insuful corresponding thereto | REVERSE PROTEOMICS RESEARCH INSTITUTE CO., LTD. (JP) | 2007-04-26 | — | — | US | disclosed |
| US-20070093536-A1 | Target protein of antidiabetic and novel antidiabetic insuful corresponding thereto | REVERSE PROTEOMICS RESEARCH INSTITUTE CO., LTD. (JP) | 2007-04-26 | — | — | US | disclosed |
| US-20070093536-A1 | Target protein of antidiabetic and novel antidiabetic insuful corresponding thereto | REVERSE PROTEOMICS RESEARCH INSTITUTE CO., LTD. (JP) | 2007-04-26 | — | — | US | disclosed |
| EP-1698696-A1 | TARGET PROTEIN OF ANTIDIABETIC AGENT AND NOVEL ANTIDIABETIC AGENT INSUFUL CORRESPONDING THERETO | Reverse Proteomics Research Institute Co., Ltd (JP) | 2006-09-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093536-A1 | Target protein of antidiabetic and novel antidiabetic insuful corresponding thereto | IGFBP4, IGF2BP1, INSRR | CYP3A4 4154/4885MAPT 4851/4885MEN1 4761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.