Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL5578200 | 0.94 | — | — | |
| Histidine SCHEMBL5577952 | 0.91 | — | — | |
| Phenylalanine SCHEMBL294177 | 0.82 | REN (0.33) | — | |
| Glutamic Acid SCHEMBL6661749 | 0.82 | — | — | |
| Proline SCHEMBL1543509 | 0.80 | — | — | |
| Lysine SCHEMBL5577931 | 0.80 | — | — | |
| Phenylalanine SCHEMBL3254715 | 0.79 | REN (0.31) | — | |
| Glycine SCHEMBL4616827 | 0.78 | — | — | |
| Histidine SCHEMBL9294075 | 0.78 | — | — | |
| Histidine SCHEMBL1896523 | 0.77 | REN (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070166699-A1 | Combination of anti-hpv-16 and 18 antibodies and uses thereof | AMYNON BIOTECH GMBH | 2007-07-19 | — | — | US | disclosed |