Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL3663298 | 0.95 | REN (0.33) | REN | |
| Phenylalanine SCHEMBL3254715 | 0.81 | REN (0.31) | REN | |
| Arginine SCHEMBL6868910 | 0.81 | APLNR (0.33) | — | |
| Histidine SCHEMBL9538044 | 0.80 | CRHR1 (0.34) | REN | |
| Asparagine SCHEMBL3252545 | 0.80 | REN (0.30) | REN | |
| Histidine SCHEMBL6544594 | 0.80 | — | — | |
| Histidine SCHEMBL8185592 | 0.78 | — | — | |
| Glutamine SCHEMBL294952 | 0.78 | REN (0.35) | REN | |
| Phenylalanine SCHEMBL294177 | 0.78 | REN (0.33) | REN | |
| Histidine SCHEMBL5577985 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9102711-B2 | Methods and materials for targeted mutagenesis | XOMA TECHNOLOGY LTD. (US) | 2015-08-11 | — | — | US | disclosed |
| US-20110118131-A1 | METHODS AND MATERIALS FOR TARGETED MUTAGENESIS | XOMA TECHNOLOGY LTD. (US) | 2011-05-19 | — | — | US | disclosed |