Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | EIF4EBP1 | Q13541 | 3/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5581974 | 0.94 | MAP4K4 (0.45) | CETPKCNH2MAP4K4KDM4EALDH1A1 | |
| SCHEMBL5581833 | 0.89 | MAP4K4 (0.39) | CETPKCNH2MAP4K4KDM4EALDH1A1 | |
| SCHEMBL5582081 | 0.89 | CETP (0.38) | CETPKCNH2MAP4K4KDM4EALDH1A1 | |
| SCHEMBL5582166 | 0.85 | ALDH1A1 (0.42) | NPC1CETPKCNH2KDM4EALDH1A1 | |
| SCHEMBL5581995 | 0.85 | CSNK2A1 (0.50) | NPC1RAB9AL3MBTL1PTK2MAP4K4 | |
| SCHEMBL5581694 | 0.85 | ALDH1A1 (0.43) | NPC1RAB9ACETPKCNH2KDM4E | |
| SCHEMBL5581741 | 0.83 | EIF4EBP1 (0.39) | PTK2EIF4EBP1PTGER1CYP2C9CYP3A4 | |
| SCHEMBL5582167 | 0.83 | KDM4E (0.41) | NPC1RAB9ACETPKCNH2KDM4E | |
| SCHEMBL5582238 | 0.82 | MAP4K4 (0.52) | MAP4K4PDE4APDE4CPDE4DTUBB4A | |
| SCHEMBL5582259 | 0.81 | ALDH1A1 (0.38) | NPC1RAB9ACETPKCNH2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225308-A1 | 2-Amino Quinazoline Derivative | KYOWA HAKKO KOGYO CO.,LTD. (JP) | 2007-09-27 | — | — | US | disclosed |
| EP-1726584-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225308-A1 | 2-Amino Quinazoline Derivative | AGTR2, ABL1, AGTR1 | NPC1 1790/4885RAB9A 324/4885L3MBTL1 1507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.