Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 7/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5581974 | 0.89 | MAP4K4 (0.45) | MAP4K4CSNK2A2CSNK2BCSNK2A1ADORA1 | |
| SCHEMBL5582212 | 0.87 | CSNK2A1 (0.49) | MAP4K4CSNK2A2CSNK2BCSNK2A1ADORA1 | |
| SCHEMBL5581752 | 0.85 | PDE4A (0.45) | MAP4K4CSNK2A1PDE4APDE4CPDE4D | |
| SCHEMBL5582205 | 0.84 | CSNK2A2 (0.52) | MAP4K4CSNK2A2CSNK2BCSNK2A1ADORA1 | |
| SCHEMBL5582245 | 0.84 | CSNK2A1 (0.51) | MAP4K4CSNK2A2CSNK2BCSNK2A1ADORA1 | |
| SCHEMBL5582178 | 0.83 | VNN1 (0.45) | MAP4K4CSNK2A2CSNK2BCSNK2A1ADORA1 | |
| SCHEMBL5582210 | 0.83 | CSNK2A1 (0.51) | MAP4K4CSNK2A2CSNK2BCSNK2A1ADORA1 | |
| SCHEMBL5581841 | 0.82 | NPC1 (0.41) | MAP4K4PDE4APDE4CPDE4DTUBB4A | |
| SCHEMBL5582252 | 0.81 | VCP (0.44) | MAP4K4CSNK2A2CSNK2BCSNK2A1ADORA1 | |
| SCHEMBL5581888 | 0.81 | ADORA1 (0.47) | ADORA1ADORA2AFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225308-A1 | 2-Amino Quinazoline Derivative | KYOWA HAKKO KOGYO CO.,LTD. (JP) | 2007-09-27 | — | — | US | disclosed |
| EP-1726584-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225308-A1 | 2-Amino Quinazoline Derivative | AGTR2, ABL1, AGTR1 | MAP4K4 1461/4885CSNK2A2 467/4885CSNK2B 662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.