Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 2/20 | 0.48 |
| ▸ | AKT1 | P31749 | 2/20 | 0.47 |
| ▸ | AKT2 | P31751 | 2/20 | 0.47 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 8/20 | 0.45 |
| ▸ | MAOA | P21397 | 5/20 | 0.45 |
| ▸ | MIF | P14174 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14524731 | 1.00 | TYR (0.48) | TYRAKT1AKT2AKT3NPC1 | |
| SCHEMBL5582483 | 1.00 | TYR (0.48) | TYRAKT1AKT2AKT3NPC1 | |
| SCHEMBL5581891 | 0.88 | MAOA (0.47) | TYRNPC1RAB9AKMT2AMAOB | |
| SCHEMBL5581887 | 0.88 | MAOA (0.47) | TYRNPC1RAB9AKMT2AMAOB | |
| SCHEMBL14524718 | 0.88 | MAOA (0.47) | TYRNPC1RAB9AKMT2AMAOB | |
| SCHEMBL6997465 | 0.74 | MAOA (0.62) | NPC1RAB9AKMT2AMAOBMAOA | |
| SCHEMBL7703579 | 0.74 | MAOA (0.62) | NPC1RAB9AKMT2AMAOBMAOA | |
| SCHEMBL1658824 | 0.67 | BAZ2B (0.43) | NPC1RAB9AMAOA | |
| SCHEMBL5582281 | 0.65 | HDAC1 (0.43) | MAOBCYP19A1 | |
| SCHEMBL27579110 | 0.65 | KMT2A (0.42) | AKT1AKT2AKT3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070087346-A1 | Orthogonal gene switches | CILIBERTO GENNARO | 2007-04-19 | — | — | US | disclosed |
| EP-1680447-A2 | ORTHOGONAL GENE SWITCHES | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005040212-A2 | ORTHOGONAL GENE SWITCHES | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070087346-A1 | Orthogonal gene switches | TCF12, JUN, TCF7 | TYR 3418/4885AKT1 4247/4885AKT2 3924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.