Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 8/20 | 0.72 |
| ▸ | CA1 | P00915 | 3/20 | 0.72 |
| ▸ | CA2 | P00918 | 3/20 | 0.72 |
| ▸ | PARP1 | P09874 | 2/20 | 0.72 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.72 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.72 |
| ▸ | CES2 | O00748 | 2/20 | 0.53 |
| ▸ | CES1 | P23141 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.50 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.50 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.50 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27457201 | 0.87 | PARP10 (0.68) | PARP10CA1CA2PARP1PARP4 | |
| SCHEMBL201761 | 0.85 | PARP10 (1.00) | PARP10CA1CA2PARP1PARP4 | |
| P-Anisic Acid SCHEMBL5584037 | 0.84 | CA1 (0.71) | CA1CA2CES2CES1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL408766 | 0.83 | PARP10 (0.95) | PARP10CA1CA2PARP1PARP4 | |
| Hydrochloric Acid SCHEMBL4376056 | 0.83 | PARP10 (0.95) | PARP10CA1CA2PARP1PARP4 | |
| Terephthalamide SCHEMBL2512049 | 0.83 | PARP1 (0.58) | PARP10CA1CA2PARP1PARP4 | |
| Methyl 4-Methoxybenzoate SCHEMBL5582912 | 0.83 | CA1 (0.72) | CA1CA2CES2CES1KMT2A | |
| SCHEMBL5582971 | 0.80 | PLK1 (0.74) | CA1CA2CES2CES1ALDH1A1 | |
| Acetic Acid SCHEMBL28396208 | 0.80 | PARP10 (0.88) | PARP10CA1CA2PARP1PARP4 | |
| SCHEMBL7442028 | 0.80 | PARP10 (0.88) | PARP10CA1CA2PARP1PARP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054894-A1 | Quinazoline potassium channel inhibitors | MERCK & CO., INC. (US) | 2007-03-08 | — | — | US | disclosed |
| CN-1856310-A | Quinazoline potassium channel inhibitors | MERCK & CO INC (US) | 2006-11-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054894-A1 | Quinazoline potassium channel inhibitors | KCNJ2, KCNH2, KCNH3 | PARP10 1272/4885CA1 3497/4885CA2 619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.