Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 2/20 | 0.74 |
| ▸ | F10 | P00742 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL837307 | 0.86 | PLK1 (1.00) | PLK1F10SMN1; SMN2HPGDTSHR | |
| Hydrochloric Acid SCHEMBL11037223 | 0.84 | PLK1 (0.96) | PLK1F10SMN1; SMN2HPGDTSHR | |
| Methyl 4-Methoxybenzoate SCHEMBL5582912 | 0.83 | CA1 (0.72) | F10SMN1; SMN2TSHRCA1CA2 | |
| P-Anisic Acid SCHEMBL5584037 | 0.81 | CA1 (0.71) | SMN1; SMN2HPGDCA1CA2CYP1A2 | |
| SCHEMBL23484773 | 0.81 | PLK1 (0.89) | PLK1F10SMN1; SMN2HPGDTSHR | |
| SCHEMBL14722006 | 0.81 | PLK1 (0.89) | PLK1F10SMN1; SMN2HPGDTSHR | |
| SCHEMBL5582839 | 0.80 | PARP10 (0.72) | F10CA1CA2ALDH1A1NPC1 | |
| Phosphonic Acid SCHEMBL1060959 | 0.80 | PLK1 (0.85) | PLK1F10SMN1; SMN2HPGDTSHR | |
| SCHEMBL28690251 | 0.78 | NPC1 (0.71) | PLK1F10SMN1; SMN2HTTCA1 | |
| SCHEMBL8717056 | 0.77 | PLK1 (0.80) | PLK1F10SMN1; SMN2HTTCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054894-A1 | Quinazoline potassium channel inhibitors | MERCK & CO., INC. (US) | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054894-A1 | Quinazoline potassium channel inhibitors | KCNJ2, KCNH2, KCNH3 | PLK1 323/4885F10 4036/4885SMN1; SMN2 4527/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.