Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.35 |
| ▸ | MYC | P01106 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | ASPH | Q12797 | 1/20 | 0.32 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL238763 | 0.81 | SMN1; SMN2 (0.46) | KDM4EMAPTALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL2006064 | 0.78 | SLC13A5 (0.41) | KDM4EMAPTALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL870085 | 0.77 | KDM4E (0.36) | KDM4EMAPTALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL118711 | 0.77 | MEN1 (0.46) | KDM4EMAPTALDH1A1L3MBTL1POLB | |
| SCHEMBL22589893 | 0.76 | ALDH1A1 (0.38) | KDM4EMAPTALDH1A1L3MBTL1POLB | |
| SCHEMBL6615497 | 0.76 | CHRM2 (0.36) | KDM4EMAPTALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL5785689 | 0.75 | ALDH1A1 (0.41) | KDM4EMAPTALDH1A1CYP3A4TSHR | |
| SCHEMBL1445867 | 0.74 | PAX8 (0.38) | KDM4EALDH1A1L3MBTL1TRIM24TRIM33 | |
| SCHEMBL23878604 | 0.73 | LMNA (0.31) | LMNAKMT2A | |
| SCHEMBL935798 | 0.72 | SSTR4 (0.38) | TRIM24TRIM33POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | MERCK SHARP & DOHME CORP. | 2007-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027321-A1 | Bipyridyl amines and ethers as modulators of metabotropic glutamate receptor-5 | GRM5, GRIK5, GRM1 | KDM4E 327/4885MAPT 448/4885ALDH1A1 2178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.