Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL5583357

Fc1ccc(N2CCNCC2)cc1.O=C(O)C(F)(F)F

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.58
ALDH1A1 P00352 3/20 0.54
TSHR P16473 2/20 0.54
USP2 O75604 1/20 0.54
HSD17B10 Q99714 1/20 0.54
ADRB1 P08588 3/20 0.50
HTR3E A5X5Y0 2/20 0.50
HTR3B O95264 2/20 0.50
HTR3A P46098 2/20 0.50
HTR3D Q70Z44 2/20 0.50
HTR3C Q8WXA8 2/20 0.50
SIGMAR1 Q99720 2/20 0.50
NPC1 O15118 3/20 0.49
RAB9A P51151 3/20 0.49
TP53 P04637 2/20 0.49
KDM4E B2RXH2 1/20 0.49
MAPT P10636 1/20 0.49
HPGD P15428 1/20 0.49
MAPK1 P28482 1/20 0.49
CASP1 P29466 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenylpiperazine SCHEMBL3979040 0.87 HTR3E (0.69) MAOBALDH1A1TSHRUSP2HSD17B10
Trifluoroacetic Acid SCHEMBL16422578 0.86 MAOB (0.46) MAOBALDH1A1TSHRUSP2HSD17B10
Trifluoroacetic Acid SCHEMBL6336692 0.86 ADRB1 (0.69) MAOBALDH1A1TSHRUSP2HSD17B10
Trifluoroacetic Acid SCHEMBL30182373 0.86 ALDH1A1 (0.53) MAOBALDH1A1TSHRUSP2HSD17B10
Trifluoroacetic Acid SCHEMBL5265518 0.84 USP2 (0.59) ALDH1A1TSHRUSP2HSD17B10ADRB1
SCHEMBL233425 0.84 ADRB1 (0.63) MAOBALDH1A1ADRB1HTR3EHTR3B
SCHEMBL894537 0.84 ADRB1 (0.63) MAOBALDH1A1ADRB1HTR3EHTR3B
Trifluoroacetic Acid SCHEMBL6392063 0.83 ALDH1A1 (0.57) MAOBALDH1A1TSHRUSP2HSD17B10
Piperazine SCHEMBL7486912 0.82 ADRB1 (0.61) MAOBALDH1A1ADRB1HTR3EHTR3B
Hydrochloric Acid SCHEMBL1005870 0.82 ADRB1 (0.61) MAOBALDH1A1ADRB1HTR3EHTR3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1851199-A1 SUBSTITUTED BIS ARYL AND HETEROARYL COMPOUNDS AS SELECTIVE 5HT2A ANTAGONISTS Aventis Pharmaceuticals, Inc. (US) 2007-11-07 EP disclosed
WO-2006086705-A1 SUBSTITUTED BIS ARYL AND HETEROARYL COMPOUNDS AS SELECTIVE 5HT2A ANTAGONISTS AVENTIS PHARMACEUTICALS INC. (US) 2006-08-17 WO disclosed