Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 1/20 | 0.35 |
| ▸ | AQP1 | P29972 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4597199 | 0.90 | GRM2 (0.42) | PARP1PTGS1PTGS2HTR1ACREBBP | |
| SCHEMBL5583517 | 0.83 | USP7 (0.37) | PTGS1PTGS2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL4597185 | 0.83 | MAOA (0.36) | PARP1PTGS1PTGS2HTR1APRKAB2 | |
| SCHEMBL4596855 | 0.81 | HTR2A (0.43) | PARP1HTR1ACREBBPBRD4AQP1 | |
| SCHEMBL4596570 | 0.81 | AQP1 (0.41) | PARP1HTR1AAQP1GRM2 | |
| SCHEMBL4220019 | 0.80 | PRKAB2 (0.58) | PTGS1PTGS2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL4231239 | 0.80 | AQP1 (0.58) | PTGS1PTGS2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL4712018 | 0.80 | AQP1 (0.40) | PARP1HTR1AAQP1GRM2 | |
| SCHEMBL4231244 | 0.79 | PRKAB2 (0.48) | PTGS1PTGS2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL4963750 | 0.79 | PARP1 (0.48) | PARP1PTGS1PTGS2HTR1ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |