Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 7/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | NQO1 | P15559 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30705448 | 0.74 | SOS2 (0.47) | SOS2HPGDSNQO1CCNCCDK8 | |
| SCHEMBL31621979 | 0.73 | NQO1 (0.42) | CYP11B1CYP11B2SOS2EGFRHPGDS | |
| SCHEMBL1993575 | 0.73 | PIK3CG (0.34) | EGFRHPGDS | |
| SCHEMBL29641000 | 0.71 | HPGDS (0.42) | CYP11B1CYP11B2EGFRHPGDSCYP19A1 | |
| SCHEMBL21379737 | 0.71 | HPGDS (0.42) | CYP11B1CYP11B2EGFRHPGDSCYP19A1 | |
| SCHEMBL14629352 | 0.71 | EGFR (0.32) | EGFR | |
| SCHEMBL1994814 | 0.71 | ALDH1A1 (0.47) | SOS2NQO1 | |
| SCHEMBL14644324 | 0.69 | CCR1 (0.41) | EGFR | |
| SCHEMBL30290906 | 0.69 | CCR1 (0.41) | EGFR | |
| SCHEMBL29644543 | 0.69 | EGFR (0.47) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007529451-A | — | — | 2007-10-25 | — | — | JP | claimed |
| EP-1727819-A1 | NOVEL DICHLORO-PHENYL-PYRIDO¬2,3-D|PYRIMIDINE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-12-06 | — | — | EP | claimed |
| WO-2005090344-A1 | NOVEL DICHLORO-PHENYL-PYRIDO [2,3-D] PYRIMIDINE DERIVATES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-29 | — | — | WO | claimed |
| EP-1739081-A1 | HYDRAZINO-SUBSTITUTED HETEROCYCLIC NITRILE COMPOUNDS AND USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-01-03 | — | — | EP | disclosed |